2015; He et al. 2023; Hu et al. 2022). Improved performance in spatial memory tasks suggests that Dex may contribute to the preservation of hippocampal function and synaptic plasticity. The reversal of STZ‐induced deficits aligns with evidence indicating that Dex enhances BDNF expression, supports neurogenesis, and partially restores disrupted insulin signaling in experimental AD models (Arslan et al. 2022; Wang et al. 2018; Yonamine et al. 2023). Here, INS is linked to Alzheimer disease.