In univariate Cox proportional hazards models, the significant predictors of HCC recurrence included ATX (≥ 1.323 mg/mL; HR: 6.49; 95% CI: 1.90–22.13; p = 0.003), FIB‐4 (≥ 3.524; HR: 2.75; 95% CI: 1.00–7.55; p = 0.050), and M2BPGi (≥ 3.524; HR: 2.12; 95% CI: 1.08–4.19; p = 0.030) (Table 3). The gene discussed is ENPP2; the disease is hepatocellular carcinoma.