Panhypopituitarism, characterized by multiple pituitary hormone deficiencies often including growth hormone (GH), thyroid-stimulating hormone (TSH), and adrenocorticotropic hormone (ACTH), has an estimated prevalence between 1 in 16,000 and 1 in 26,000 individuals (1). The gene discussed is POMC; the disease is hypopituitarism.