The main causes of death in the SSc-ILD were infections (72.7%), pulmonary hypertension (PH, OR = 18.81, 95% CI = 2.11-167.70), and renal failure (OR = 33.6, 95% CI = 2.00-546.10).<h4>Conclusion</h4>The SSc-ILD have lower TLC/DLCO, higher CRP, and poorer renal function than the SSc without ILD. The gene discussed is CRP; the disease is kidney failure.