Glucose-stimulated insulin secretion was increased after overexpression of miR-122-5p or miR-223-3p and cell viability was decreased after overexpression of miR-34a-5p in insulin-secreting cells.<h4>Conclusions/interpretation</h4>MiR-34a-5p and miR-122-5p show potential as biomarkers for CFRD development and liver damage. Here, INS is linked to cystic fibrosis-related diabetes.