Tumor-infiltrating lymphocytes (TIL) were assessed by immunohistochemistry (IHC) on tissue microarrays (TMA), complemented by digital analysis for standardized quantification.<h4>Results</h4>Our results highlight the influence of CD4+ T cells on short-term outcomes: high CD4+ T-cell levels were significantly associated with achieving pCR. Here, CD4 is linked to neoplasm.