To evaluate whether leptin modulated the relationship between psychological stress and gonadotropin dynamics, a moderation model tested in PCOM–STRESS showed a significant interaction between stress and leptin in predicting the LH/FSH ratio (B = − 0.001, p = 0.004, 95% bCa CI [–0.001, − 6.04 × 10−5]; R2 = 0.27). This evidence concerns the gene BRD2 and psychosocial stress measurement.