TARDBP and amyotrophic lateral sclerosis: Distinct TDP-43 protein isoforms arising from ALS-associated mutations, alternative splicing, or posttranslational cleavage exhibit divergent protein half-lives from WT TDP-43 (Berning and Walker, 2019; Brower et al., 2013; Flores et al., 2019; Pesiridis et al., 2011; Scotter et al., 2014; Watanabe et al., 2013), implying distinct clearance pathways are likely used.