TBK1 and amyotrophic lateral sclerosis: Another familial ALS gene and kinase, TBK1 (Cirulli et al., 2015; Freischmidt et al., 2015) phosphorylates endosomal proteins (including Rab7), may modulate Rab7 GTPase activity (Heo et al., 2018), colocalizes with early endosome markers (Chau et al., 2015), and leads to severe defects in endolysosomal trafficking and lysosomal acidification when absent in motor neurons (Hao et al., 2021, Preprint).