Atrial natriuretic peptide and brain natriuretic peptide have been shown to stimulate lipolysis in human adipocytes and the upregulate Ucp1 expression in WAT, along with increased resting energy expenditure in mice injected with BNP, suggests that BNP may be involved in to browning and PEW in CKD [63]. This evidence concerns the gene UCP1 and chronic kidney disease.