Current CRC-adipose browning research is limited by small clinical cohorts, insufficient study of subtype differences and unclear crosstalk between the miR-146b-5p/HOXC10 and MIIP/AZGP1 pathways, while targeting pro-browning mechanisms paired with browning-related biomarkers for patient stratification could improve outcomes in advanced, especially cachectic, CRC patients. This evidence concerns the gene AZGP1 and colorectal carcinoma.