TNFRSF1A and neoplasm: Beyond antigenic escape, tumor cells develop resistance by evading the core cytotoxic mechanisms of CAR-T cells, which execute killing primarily through the perforin/granzyme pathway, death receptor signaling [e.g., FAS, tumor necrosis factor receptor 1 (TNF-R1), and TRAIL and/or its death receptors (TRAIL-R1/2), and cytokine-mediated pathways like interferon-γ (IFN-γ) [25].