The ROC curve showed that there no significant statistical difference in the PFS with patients with different SPP1 expression levels (p  > 0.05) (Figure 8C), and there was no significant statistical difference in the expression of SPP1 between NSCLC patients with and without immune response (p  > 0.05) (Figure 8D,E). This evidence concerns the gene SPP1 and non-small cell lung carcinoma.