Our inability to fully adjust for them in the primary multivariate model weakens the claim of the indicator’s complete “independence.” However, the biological rationale for the indicators reflecting systemic host factors (inflammation, nutrition) distinct from tumor‐intrinsic molecular pathways (MGMT/IDH), combined with extreme accessibility and low cost, suggests they could still offer valuable complementary or practical prognostic information, especially where molecular testing is unavailable. This evidence concerns the gene MGMT and neoplasm.