PBMC analysis identified upregulation of proinflammatory genes (CXCL2, CXCL3, DEFA3, EMP1, HBD, SMAD7, SPRR1B) and downregulation of genes (CD246, KLHL34, MCF2L‐AS1, NOG, NRCAM, RAD54B, SLC4A10, VSIG1) in DKD patients (Figure 5C,D; Supporting Information 4: Figure S4G,H). The gene discussed is SMAD7; the disease is diabetic kidney disease.