DEGs and mitochondrial‐related DEGs in each cell type are presented in Supporting Information 4: Figure S4B and Figure 4B. Among mitochondrial genes with causal effects on DKD, ATP5MC3 and NT5DC2 were downregulated in PODOs, while GLYCTK was downregulated in LOH and PCT (Figure 4C–F; Supporting Information 4: Figure S4C,D), aligning with their inverse associations with DKD risk in MR analysis. This evidence concerns the gene NT5DC2 and diabetic kidney disease.