Additionally, CD4+ TCs and CD8+ TCs in vitiligo exhibited an enhanced communication to Mac‐InflamAP that regulated antigen presentation (PTPRC ‐ MRC1), chemokine (MIF signaling), inflammation (IL16 ‐ CD4), and T cell costimulation (CD6 ‐ ALCAM and CD55 ‐ ADGRE5), indicating a positive feedback loop that may perpetuate the inflammatory response. The gene discussed is ADGRE5; the disease is vitiligo.