Unexpectedly, it was observed a decline in Foxj2 mRNA expression levels in the adipose tissue of mice with obesity induced by a high‐fat diet (HFD) (Figure 5A), as well as in the livers of mice with nonalcoholic fatty liver disease (NAFLD) induced by HFD (Figure 5B). Here, FOXJ2 is linked to obesity due to melanocortin 4 receptor deficiency.