Moreover, in the in vivo animal experiment, a decrease in Foxj2 levels was observed in the pathological process of several inflammation‐related diseases, including HFD‐induced obesity, NAFLD, Dox‐induced cardiomyopathy, AMI and D‐gal induced aging conditions, suggesting that Foxj2 may play diverse and potentially context‐specific roles in various inflammatory diseases. The gene discussed is FOXJ2; the disease is obesity due to melanocortin 4 receptor deficiency.