Traditionally, LDL pathway abnormalities have been considered mainly involved in tumor cell proliferation and metabolism, but our single‐cell analysis revealed that LDL signaling is significantly upregulated not only in malignant epithelial cells but also in key microenvironmental components such as CAFs and SPP1+ macrophages, while certain vascular endothelial cells and DCs exhibited low expression. Here, SPP1 is linked to neoplasm.