NKILA facilitated proliferation, invasion, Warburg effects, and autophagy of ICC cells by regulating mammalian target of rapamycin (mTOR) pathway, PD‐L1 expression, and CD8+ T cytotoxicity, while dichloroacetate (DCA) could reverse these effects. The gene discussed is NKILA; the disease is intrahepatic cholangiocarcinoma.