Our research findings indicated that the Warburg effect inhibitor DCA stimulated the autophagy pathway and counteracted the effects of NKILA overexpression on autophagy‐mediated immune evasion, which innovatively links the NKILA‐mediated Warburg effect to autophagy‐mediated immune evasion in the progression of ICC. The gene discussed is NKILA; the disease is intrahepatic cholangiocarcinoma.