Next, we constructed a mouse ICC model using HuCCT1 (Figure 6) or RBE cells (Supporting Information 3: Figure S3) and found that NKILA silencing inhibited tumor growth compared to KD‐NC + OE‐NC, which was reversed by MTX1 overexpression (Figure 6A,B, Supporting Information 3: Figure S3A–C, p  < 0.05). The gene discussed is MTX1; the disease is intrahepatic cholangiocarcinoma.