To obtain more precise CAFs clusters with stronger associations to gliomas, we selected three clusters characterized by high expression of cancer‐related marker genes: actin alpha 2 (ACTA2), platelet‐derived growth factor receptor beta (PDGFRB), THY1, and collagen type I alpha 1 chain (COL1A1), specifically clusters 19, 25, and 27. Here, ACTA2 is linked to central nervous system cancer.