Zhao et al. [8] found that PAD4 expression is upregulated in LPS‐induced ALI, and its selective inhibitor, Thr‐Asp‐F‐amidine (TDFA), can significantly reduce pulmonary edema, inflammatory infiltration, and oxidative stress, protect the integrity of the alveolar epithelial barrier, and improve survival rates. Here, PADI4 is linked to acute respiratory distress syndrome.