Furthermore, indicators of liver fibrosis encompassed reduced levels of albumin, antioxidants; glutathione (GSH), superoxide dismutase (SOD), heme oxygenase‐1 (HO‐1), and nuclear factor erythroid 2‐related factor 2 (Nrf2), antiapoptotic protein B‐cell lymphoma‐2 (BCL2), sirtuin‐1 (SIRT1) expression, and histopathological alterations. This evidence concerns the gene HMOX1 and Hepatic fibrosis.