In addition to the expression of granzyme B alongside other cytotoxic molecules, these CD4+ T cells produce high levels of IFN-γ and IL-17, accumulate in inflammatory autoimmune lesions, are autoreactive and have cytolytic capacity towards target tissues; for example, in MS they have been shown to kill oligodendrocytes (69–73). The gene discussed is GZMB; the disease is myeloid sarcoma.