CLDN1 and colitis: Counteracting the establishment and persistence of visceral hypersensitivity in a rat model of colitis induced by 2,4-DNBS. Direct modulation of inflammation and nociception. It contributes to restore the IEB integrity, as evidenced by LBP levels and higher expression of claudin-1, and to reduce both enteric and spinal glial cell activation, linked to pain chronicity.