Recently, the Sinha group developed an in vitro MFS‐iPSC model, using iPSC‐derived smooth muscle cells to elucidate the role of TGF‐β signaling in MFS pathogenesis, and identified a novel role of p38 and KLF4 in the MFS pathogenesis [18]. The gene discussed is TGFB1; the disease is Marfan syndrome.