Moreover, elevated levels of IKBKE perpetuate the stimulation of the NF‐κB signal transduction cascade, leading to the upregulation of Bcl‐2, which in turn suppresses programed cell death and fosters the survival and multiplication of tumor cells, while also augmenting the migratory and invasive potential of GBM cells [32, 33]. The gene discussed is NFKB1; the disease is glioblastoma.