As illustrated in Figure 1B, we screened for genes intimately linked to the prognostic outcome of GBM and found that BRCA1, CHEK2, IKBEKE, and PPIA constituted adverse indicators for the prognostic trajectory of GBM patients, whereas ZMYND11, MAPK8, RPS3, and GHITM were protective factors. This evidence concerns the gene CHEK2 and glioblastoma.