The mechanism may involve COVID‐19 invading cells through ACE2 receptors and activating the renin‐angiotensin system (RAS), leading to an increase in angiotensin II, which causes vasoconstriction and an increase of platelets and white blood cells, thus inducing thrombosis; Another possible mechanism is that COVID‐19 infiltration can lead to retinal vasculitis, rupture of the blood retinal barrier, and retinal degeneration, with red blood cells and immune cells infiltrating surrounding tissues. This evidence concerns the gene REN and retinal degeneration.