MA10 infection induced six down-regulated (Pllp, Malat1, Myrf, Mag, Ptgds, Ugt8a) and two upregulated DEGs (Sgk1, Mbp), while Aβ pathology resulted in one down-regulated (Hmgb1) and ten up-regulated DEGs (Apoe, B2m, Clu, Cstd, Gfap, Psen1, Pllp, Cst7, Cd9, Plp1) (Supplemental Figure 8G). Here, HMGB1 is linked to infection.