There were increased numbers (p<0.0001) of MAC2-positive cells in the brains of uninfected 5xFAD mice compared to uninfected WT mice, reflective of the neuroinflammation occurring within the brains of the 5xFAD mice as a result of ongoing AD neuropathology and Aβ plaque accumulation (Supplemental Figure 1). This evidence concerns the gene LGALS3 and Alzheimer disease.