PSEN1 and infection: MA10 infection resulted in six additional down-regulated (Cpe, B2m, Pltp, Sparc, Cldn5, Vtn) and four up-regulated DEGs (Slc2a1, Vim, Apod, Acta2), whereas Aβ pathology alone produced one down-regulated (Slc2a1) and three upregulated DEGs (Gfap, Psen1, Clu) (Supplemental Figure 8B).