PSEN1 and infection: MA10 infection induced seven additional down-regulated (Hsp90aa1, Tcf7l2, Gnas, Sparcl1, Ywhag, Cpe, Sparc) and four upregulated DEGs (Ppp1r1b, Penk, Arpp21, Pcp4), whereas Aβ pathology resulted in five down-regulated (Cplx1, Syp, Meg3, Snhg11, Penk) and one upregulated DEG (Psen1) (Supplemental Figure 8L).