Furthermore, there was no increase in MAC2+ monocyte/macrophages within the brains of MA10-infected WT or 5xFAD mice at day 21 p.i. MA10 infection did not elicit changes in either astrocyte number or volume at day 21 p.i., and although one study has associated infection with trending increases in GFAP expression in the brains of infected laboratory mice 3 days p.i.63; however other reports have not found any significant increases in astrocyte numbers at 6 or 30 days p.i. 66. This evidence concerns the gene GFAP and infection.