CES4A and cancer: The amplified gene families found on the gorilla acrocentrics obviously raise questions of adaptation, and these genes are broadly associated with common drivers of rapid evolution, including immunity and inflammation (ABHD17A, C1QTNF3, GGT, SAFB2), metabolism and detoxification (C1QTNF3, CES4A, GGT, LRPAP1), musculoskeletal development (FGFR3, FRG1), reproduction (SAFB2, TPTE), and cancer/testis genes (BAGE2, TPTE).