To evaluate the impact of the leukemic fusion genes on the course of an adenoviral infection, we created stable B cell lines expressing either the RUNX1 fusion gene commonly associate with ALL (ETV6/RUNX1), or the RUNX1 fusion gene commonly associated with acute myeloid leukemia (RUNX1/MTG8) (58, 59). This evidence concerns the gene RUNX1T1 and acute lymphoblastic leukemia.