To further investigate the differences in macrophage phenotype based on APOL1 genotype, we generated bone marrow derived macrophages (BMDMs) and exposed them to interferon gamma (IFNγ) and/or oxidized low-density lipoprotein (OxLDL), mimicking the hyperlipidemia often seen in metabolic syndrome, to induce inflammation. The gene discussed is APOL1; the disease is metabolic syndrome.