AGTR2 and acute myeloid leukemia: Phenotypes associated with enforced Agtr2 expression, including altered cell metabolism (Fig. 7E to I), mouse survival (Fig. 7J), leukemic burden (Fig. 7K), AML cell cycle (Fig. 7L), and AML stemness (Fig. 7M) were rescued by re-introduction of Srebf1, indicating AT2R activation suppressed SREBP1 activation to limit FA utilization in AML cells.