Similar to CD34-expressing AML cells, CD34-non-expressing AT2R− cells showed higher clonogenicity (Fig. 3D) and specific ability to repopulate immunodeficient mice (AT2R− cells, 56 engrafted out of 56 transplanted mice (100%); AT2R+ cells, 0 engrafted out of 56 transplanted mice (0%); Fig. 3E and F; Fig. S2B to D). This evidence concerns the gene CD34 and acute myeloid leukemia.