AGTR2 and acute myeloid leukemia: In contrast, AML samples show specific loops between AGTR2 and a cluster of co-occurring silencers around 250 kb upstream, marked by increased deposition of H3K27me3 (Fig. 4B, right), indicating Polycomb-mediated transcriptional repression, and reduced chromatin accessibility based on ATAC-seq signal (Fig. 4B, right), suggesting that the locus becomes physically inaccessible.