In AML samples that display high expression of CD34 (Fig. 3H; Fig. S2E), CD34+AT2R+ showed no clonogenicity and in vivo AML engraftment (Fig. 3J and K; Fig. S2F and G), suggesting AT2R is a potential marker to stratify and enrich LSCs in both CD34-expressing and -non-expressing AML cases. Here, CD34 is linked to acute myeloid leukemia.