Lin− (B220− CD19− CD3− CD8− CD11b− Gr-1− TER119− NK1.1−) cells from C57/B6 donor mice infected by the retroviral oncogene (MLL-AF9; MA919 or AML1-ETO9a; AE920)−internal ribosome entry site (IRES)−green fluorescent protein (GFP) were used to induce AML as previously described (Fig. S4A)21,22. The gene discussed is RUNX1; the disease is acute myeloid leukemia.