Our study of pathway analysis on the shared upregulated gene set was mainly enriched in “G0:0043122: regulation of canonical NF‐kappaB signal transduction,” “M166: PID ATF2 PATHWAY,” and “G0:0002718: regulation of cytokine production involved in immune response.” These results provided critical insights into the potential mechanisms by which herpes keratitis might influence the PD, highlighting the inflammatory processes. Here, NFKB1 is linked to Parkinson disease.