After continuing to add the composite variables of age, BMI, UA, TG, HDL‐C, and HOMA‐IR to Model 1 (Model 2), the risk of MS in T2DM patients increased 6.649‐fold (95% CI: 2.224–19.885, p < 0.001), and the results demonstrated that GDF15 was an independent risk factor for MS in the combination with T2DM (p < 0.05, Table 5). Here, GDF15 is linked to type 2 diabetes mellitus.