The study analysis showed that GDF15 has a certain diagnostic significance for T2DM combined with MS (p < 0.05), and the analysis of the ROC curve (Figure 2) showed that the value of the area under the GDF15 curve was 0.793, with an optimal cut‐off value of 395.81 pg/mL, a sensitivity of 0.71, and a specificity of 0.73 (Table 6). This evidence concerns the gene GDF15 and type 2 diabetes mellitus.