Considering the existing research, which highlights the interplay between LSD1 and various kinase signaling pathways in several cancer models, including PI3K/AKT/mTOR and MEK/ERK,25–33 our laboratory sought to understand how LSD1 and its inhibition influence the kinase signaling pathways critical in the regulation of glioblastoma growth and survival. The gene discussed is KDM1A; the disease is glioblastoma.