Considering the existing research, which highlights the interplay between LSD1 and various kinase signaling pathways in several cancer models, including PI3K/AKT/mTOR and MEK/ERK,25–33 our laboratory sought to understand how LSD1 and its inhibition influence the kinase signaling pathways critical in the regulation of glioblastoma growth and survival. This evidence concerns the gene AKT1 and glioblastoma.