At 12 weeks of age, while CBP-treated Nf1OPG mouse nerve volumes were unchanged (0.99-fold change; Figure 1B), there was a reduction in optic nerve tumor proliferation to levels comparable to Nf1+/- mice, as measured by the percentage of Ki67+ cells, compared to untreated Nf1OPG mice (Figure 1C). Here, MKI67 is linked to optic nerve neoplasm.