Visualization of cfChIP-seq and RNA-seq profiles across EZH2 and BCL2, representative genes with established functions in DLBCL,59,60 revealed depletion of H3K27me3 over the gene bodies and strong enrichment of H3K4me3 at the promoters (Figure 5C). The gene discussed is EZH2; the disease is diffuse large B-cell lymphoma.