When H3K27me3 profiles were integrated into our analysis, we observed distinct histone modification patterns within genes that are differentially expressed between GCB and ABC DLBCL,67 including LYPD6B,68TOX2,69 and CD44. 70Thus, we suggest that profiling histone modifications associated with both active and repressive chromatin states from cfChromatin could improve the phenotypic characterization of certain cancers that undergo substantial epigenomic dysregulation, resulting in significant changes in gene expression and chromosome stability.71 This evidence concerns the gene CD44 and diffuse large B-cell lymphoma.