Common approaches include oral contraceptives for menstrual regulation, insulin sensitizers (e.g. metformin, pioglitazone, glucagon-like peptide-1 agonists) for metabolic homeostasis, and antiandrogens (e.g. spironolactone, statins) for hirsutism and acne (16, 17). The gene discussed is INS; the disease is Hirsutism.