Composed of collagens, glycoproteins, and proteoglycans, the oncomatrix can alter matrix stiffness and composition, promoting chemokine signaling such as CCR2-CCL2 interactions that drive monocyte recruitment and polarization toward pro-tumorigenic states, as evidenced by our MR findings (OR: 1.437 for benign and 1.311 for malignant thymomas, P < 0.002). This evidence concerns the gene CCL2 and thymic carcinoma.