Previous researcher reported that PH2 is a genetic disorders due to mutation in GRHPR gene[9,10]. Chatterjee et al identified mutation of GRHPR gene (c.494 G>A) which is consistent with our study and reported that mutation in GRHPR gene leads to the reduction of glyoxylate to glycolate and its subsequent reconversion back to glyoxylate, which is the dual enzyme activity of glyoxylate reductase and hydroxy pyruvate reductase which leads to kidney stones and HP2[11]. This evidence concerns the gene GRHPR and nephrolithiasis.