Considering the critical role of chromatin remodeling in gene expression and development[11,12], we hypothesize that SMARCA2 mutation(s) might disrupt these tightly regulated processes required for the proper development and function of ocular structures, e.g., impaired optic nerve development or retinal ganglion cell differentiation[12,13], and could lead to congenital glaucoma or other ocular phenotypes. This evidence concerns the gene SMARCA2 and congenital glaucoma.