Our research results demonstrate that ECG alleviates sepsis-induced ALI by inhibiting the NLRP3/Caspase-1/GSDMD signaling pathway-mediated pyroptosis, the Bcl-2/Bax/Caspase-3 signaling pathway-mediated apoptosis, and regulating the ZBP1/MLKL/RIPK1 signaling pathway-mediated necroptosis. Here, GSDMD is linked to acute respiratory distress syndrome.