Previous study suggested that Pgc-1α mRNA levels significantly correlated with Glut4 mRNA levels in adipose tissues.(35) The upregulated PGC-1α due to AKG intake may induce the high GLUT4 levels in adipose tissue, and this adaptation resulted in attenuating the hyperglycemia of diabetic mice in this study. Here, PPARGC1A is linked to Hyperglycemia.