STAT3 and lung cancer: Additionally, using a spindle and kinetochore-associated complex lung cancer cell line [A549 with a signal transducer and activator of transcription 3 (STAT3)-driven luciferase reporter], SP2509 was identified as a STAT3 signaling inhibitor (2.5–10 μM) that suppressed cell growth (IC50 = 3.085 μM for A549) and induced apoptosis through Janus kinase (JAK)/STAT3 modulation (Zhen et al., 2021).