Given the critical role of cholangiocytes in CCA pathogenesis and the experimentally validated oncogenicity of the FGFR2::SHTN1 fusion in CCA, we investigated baseline expression of both genes in healthy human cholangiocytes using publicly available single-cell RNA sequencing data from deceased donor liver cells (MacParland et al., 2018; Speir et al., 2021). The gene discussed is SHTN1; the disease is cholangiocarcinoma.