Interestingly, alongside its function in cytoskeletal reorganization, Shootin1 has recently been implicated in the initiation and progression of various cancers, including bladder, lung, breast, and brain (Uguen and De Braekeleer, 2016; Qin et al., 2019; Li et al., 2020; Nicolò et al., 2023; Morin et al., 2024; Wang et al., 2024). Here, SHTN1 is linked to cancer.