Mutations in CHCHD2 and CHCHD10 contribute to multiple types of neurodegenerative disorders (Jiang et al. 2022; Ikeda et al. 2022) including amyotrophic lateral sclerosis, Parkinson's disease, and frontotemporal dementia, but have not been observed to be lost in aging. The gene discussed is CHCHD2; the disease is amyotrophic lateral sclerosis.