CHCHD2 and neurodegenerative disease: CHCHD10 and CHCHD2 are mitochondrial proteins that reside in the intermembrane space and regulate electron flow through the electron transport chain during oxidative phosphorylation (Genin et al. 2016; Aras et al. 2015), and have been linked to multiple neurodegenerative diseases (Kee et al. 2021; Lu et al. 2022).