Mutations in CHCHD2 and CHCHD10 contribute to multiple types of neurodegenerative disorders (Jiang et al. 2022; Ikeda et al. 2022) including amyotrophic lateral sclerosis, Parkinson's disease, and frontotemporal dementia, but have not been observed to be lost in aging. Here, CHCHD10 is linked to amyotrophic lateral sclerosis.