Perturbations to muscle mitochondrial signaling through overactivation of mTORC1 (Ham et al. 2020) or loss of the antioxidant enzyme superoxide dismutase 1 (Jang et al. 2010) (SOD1) induces sarcopenia‐like features in NMJs such as denervation, fragmentation of AChRs, and loss of muscle function. Here, SOD1 is linked to sarcopenia.