SMAD2 and pulmonary fibrosis: 2010, Wang et al. 2022). A growing body of evidence has elucidated the molecular mechanisms by which nestin contributes to fibrosis progression. For example, in pulmonary fibrosis, nestin is upregulated in lung myofibroblasts and plays a key profibrogenic role by facilitating the Rab11‐dependent recycling of TβRI (Wang et al. 2022). Similarly, in liver fibrosis, TGF‐β induces nestin expression in hepatic stellate cells, creating a positive feedback loop that amplifies the TGFβ‐Smad2/3 pathway (Chen et al. 2021).