Immunoprecipitation of THOC1 in GBM and non-cancerous lines revealed stronger THOC1-SIN3A interaction in all three GBM lines compared to neural stem cells and astrocytes, supporting the notion that THOC1 upregulation in GBM may enable greater interaction with SIN3A (Fig. 4L, M). The gene discussed is THOC1; the disease is glioblastoma.