NOS3 and Insulin resistance: These findings are consistent with reports suggesting that the ACE DD genotype is associated with increased blood pressure, insulin resistance and hyperlipidemia all of which are established risk factors for CAD.[31,32] In contrast, no significant association was observed between eNOS-786 polymorphism and these clinical parameters, reinforcing the notion that this polymorphism may have a lesser impact on CAD risk in our study population.