The ACE I/D polymorphism has been widely studied in relation to CVDs, with several studies indicating its role in modulating blood pressure regulation and vascular remodeling.[14,15] Our results demonstrated that the deletion (D) allele was significantly more frequent among CAD patients (75%) compared to controls (40%), with an OR of 4.76 (95% CI:3.21–7.08, P < .001). The gene discussed is ACE; the disease is coronary artery disorder.