First, in the information-theoretic analysis of the pan-cancer data, the entropy values of the clusters, ENPP1 expression, and HRD score were 0.80, 3.04, and 2.94, respectively, whereas the pairwise mutual information between the clusters and ENPP1 expression, and between the clusters and HRD score were 0.66 and 0.02, respectively. Here, ENPP1 is linked to cancer.