SGPL1 and amyloidosis: Multisystem amyloidosis associated with sphingosine-1-phosphate lyase 1 (SGPL1) mutation is a rare and genetically complex disease, supported by emerging evidence linking SGPL1 dysfunction to aberrant sphingolipid metabolism and amyloidogenesis.[9,10] Epidemiologically, this condition exhibits an extremely low incidence rate (no precise statistics are available due to its rarity, with only sporadic case reports documented globally), and affects patients across a wide age spectrum, ranging from adolescents to elderly individuals.