Beyond its role in maintaining colloidal osmotic pressure, albumin also possesses antioxidant, anti-inflammatory, transport, endothelial-stabilizing, and immunomodulatory properties.[11] Albumin synthesis depends on nutritional status and is influenced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-6, which can suppress protein synthesis.[12] This explains the frequent occurrence of hypoalbuminemia in patients with septic shock. This evidence concerns the gene TNF and Hypoalbuminemia.